Pathological Patterns of Biliary Disease. A comparative analysis of PTFE-covered and uncovered stents for palliative treatment of malignant extrahepatic biliary obstruction. Primary Biliary Cirrhosis Evolves from inflammatory destruction of intrahepatic bile ducts. Cholestasis can broadly be divided into that caused by mechanical obstruction, and that caused by non-obstructive or hepatocellular causes. Am. 1). 80% are middle aged women. Biliary atresia • Biliary atresia (BA) is a congenital biliary disorder, which is characterised by an absence or severe deficiency of the extra-hepatic biliary tree. J. Roentgenol. The disease is manifested by inflammation and subsequent obstruction of the extrahepatic bile ducts, fibrosis and liver failure. Extrahepatic bile ducts and the gallbladder appear normal (filled with bile) in patients with peripheral cholangiocarcinoma. • Most common causes of neonatal cholestasis, often causing cirrhosis immediately and leading to death and accounts for over half of children who undergo liver transplantation. Disorders of the biliary tree may be either primary or secondary and involve the extrahepatic system, intrahepatic system, or a combination of the two. The smooth outlines of the narrowed duct suggest a … Mirizzi syndrome refers to an uncommon phenomenon that results in extrinsic compression of an extrahepatic biliary duct from one or more calculi within the cystic duct or gallbladder.It is a functional hepatic syndrome but can often present with biliary duct dilatation and can mimic other hepatobiliary pathologies such as cholangiocarcinoma 2. Peripherally located tumors cause segmental or lobular obstruction of the biliary tree. Gwon DI, Ko GY, Kim JH. 90% of patients have other autoimmune disease. 195(6), W463–W469(2010).& A good prospective study from a group leading research in the field of biliary intervention. Table 32.1 lists the causes of cholestasis. Bile flow from the rest of the liver is preserved. 7). the extrahepatic ducts were dilated proxi-mallv with agradual, smooth tapering of the intrapancreatic portion ofthe common duct which was compressed medially bya pseudocyst just above the ampulla (Fig. Nonspecific histological findings present in all forms of chronic biliary disease include ductopenia, ductular reaction, and cholestasis (Fig. Due to prolonged biliary obstruction from gall tones, CA of head of pancreas, or scarring from surgery. and extrahepatic ducts along with significant dilation of the gallbladder. Biliary atresia (BA) is a devastating liver disease of unknown etiology affecting children generally within the first 3 months of life. Mechanical obstruction may develop in either the extrahepatic biliary …
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